Principal Investigator

Dr. Martijn Verdoes ResearcherID:A-4911-2015

Martijn.Verdoes@Radboudumc.nl

Martijn Verdoes obtained his Masters degree in Chemistry from Leiden University in 2004 and his PhD degree in Organic Chemistry from Leiden University in 2008. His thesis work mainly focused on the design and synthesis of activity-based inhibitors and probes to study proteasome function. In 2009, Martijn got awarded a NWO Rubicon Fellowship and he joined the lab of Matthew Bogyo at the Stanford School of Medicine, California, USA, where he designed and synthesized quenched activity-based probes (qABPs) for non-invasive imaging of cancer. Inspired by the observation that his qABPs got activated in specific immune cells in tumors he joined the Tumor Immunology Department in the Radboud Institute for Molecular Life Sciences (RIMLS) in 2013. In 2015, he got awarded an ERC Starting Grant and an Institute of Chemical Immunology Tenure Track Fellowship. Martijn Verdoes is an Assistant Professor at the Department of Tumor Immunology and is affiliated with Bio-organic Chemistry at the Faculty of Science, Radboud University.

Postdocs

Olga Ilina, PhD

olga.ilina@radboudumc.nl

Olga received her PhD degree in the Radboud Institute for Molecular Life Sciences. During her PhD she studied how cancer cells invade within the tissue and spread to distant organs. By monitoring cell-cell and cell-stroma interactions using intravital multiphoton microscopy she studied how intracellular adhesion influences the ability of tumor cells to spread and how local tissue geometry modulates cell invasiveness. During her study Olga developed a strong interest in how host cells within the local microenvironment promote tumor growth and how tumor cells evade immune response. Fascinated by the possibility of targeted manipulation of specific immune cells to activate anti-tumor immune response, she joined Verdoes Lab in the Tumor Immunology Department. The goal of her current project is to use cathepsins activity-based probes to eliminate immunosuppressive tumor-associated macrophages.

Eliézer Jäger, PhD - Czech Academy of Sciences fellowship

Eliezer.Jager@radboudumc.nl

Eliezer Jäger received his PhD in 2015 at the Faculty of Natural Sciences of the Charles University of Prague, Czech Republic. His PhD studies focused on the synthesis and characterization of biological environmentally responsive (pH, temperature and reactive oxygen species) and non-responsive polymer drug delivery systems (micellar, soluble polymers, NPs). In 2016 he obtained a postdoctoral grant from the Czech Academy of Sciences for starting researchers aiming at the development of multi-responsive dendritic cell-targeted nanovaccines, as well as, tumor “chemical-environment” responsive nanomedicines under supervision of Prof. Carl Figdor and Dr. Martijn Verdoes.

PhD Students

Felix Fennemann, MSc ResearcherID:O-2976-2016

Felix.L.Fennemann@radboudumc.nl

Felix Fennemann obtained his Master Degree in Molecular Mechanisms of Disease from the Radboud University Nijmegen and Institute for Molecular Life Sciences in 2016. He discovered his passion for tumor immunology and immunotherapy throughout internships in Nijmegen on dendritic cells and dendritic cell vaccines. He wrote his masterthesis at the Cancer Center Karolinska in Stockholm about modulation of the immunosuppressive tumor microenvironment as a novel anti-cancer therapy.

In his PhD, Felix is working at the intersection of immunology, genetics and chemistry and explores possibilities for the development of smart, personalized anti-cancer therapeutics.

 

 

Iris Hagemans, MSc

Iris.Hagemans@radboudumc.nl

Iris obtained her BSc in Chemistry at Radboud University Nijmegen and her MSc degree in Chemistry at Leiden University in September 2015. Iris has always been part chemist, part biologist: she took a lot of Molecular Life Science courses in her bachelor’s degree, and in her master’s, she did one organic synthetic internship at the department of Medicinal Chemistry (Leiden University) and one cell biology internship at OncoRay in Dresden, an institute for Research in Radiation Oncology. The ultimate goal was always to combine chemistry and biology, since she believes that when the two come together, that’s where the magic happens.

In her PhD project she is able to combine these two expertises by working on a molecular toolbox for developing novel and improved checkpoint inhibitors. Checkpoint inhibitors block immunosuppressive signals generated by tumor cells. Breakthroughs in the field of these checkpoint inhibitors have even been called the scientific breakthrough of the year 2013. However, the systemic character of this type of therapy has a significant drawback: it elicits auto-immune reactions. The goal of the current project is to generate optimized molecular immune checkpoint-inhibitory approaches.

 

Floris van Dalen, MSc Researcher ID: M-8813-2017

Floris.vanDalen@radboudumc.nl

Floris van Dalen obtained his Master's degree in Chemistry at the University of Leiden in 2017. His Master thesis focused on using chemical tools to elucidate the molecular wheelwork of retrograde signaling in the endocannabinoid system. His doctoral thesis will concentrate on the development of small molecule inhibitors targeted at cysteine cathepsins. These endo/lysosomal proteases are highly upregulated in tumor-associated immune cells and play a pivotal role in tumorigenic processes as proliferation, invasion and metastasis. The primary aim of the project is to exploit this elevated cathepsin-activity to conceive a self‑regulated drug delivery system.​

 

 

Co-supervision PhD Students

Bas van der Schoot, MSc

Bas.vanderSchoot@Radboudumc.nl

Bas was the first to join the Verdoes Lab in 2014 after obtaining his master degree in Science and Business Management at the University of Utrecht. During his Master internships he gained valuable knowledge regarding vaccine design (Crucell) and antibody development (arGEN-X). Bas is interested In the development of novel tools to further advance the field of immunotherapeutics and is currently working on the development and targeting of nanovaccines for cancer immunotherapy. Bas his primary advisor is Prof. Carl Figdor.

Camille Le Gall, MSc Researcher ID: R-4950-2017

Camille.leGall@radboudumc.nl

Originally from Paris, France, Camille obtained in 2017 her MSc in Immunology from the University Pierre and Marie Curie and her engineering degree from AgroParisTech. During a master internship in 2015 at the Whitehead Institute (Boston), she became fascinated by immunology, while gaining experience in working with single domain antibodies. She wrote her master thesis at Harvard Medical School in Boston, focussing on understanding immunomodulatory mechanisms in the liver.

During her PhD, she is interested in developing targeted carrier nanoparticlated systems delivering immunomodulatory signals to dendritic cells for cancer immunotherapy. Camille's primary advisor is Prof. Carl Figdor.

Jorieke Weiden, MSc Researcher ID: M-5843-2015

Jorieke.Weiden@radboudumc.nl

Jorieke Weiden obtained her Master Degree in Biomedical Sciences from the Radboud University Nijmegen in 2014. Intrigued by cancer and how it interacts with the immune system, she performed an internship on identification of a novel cytogenic subgroup in leukemia in Newcastle-upon-Tyne in the UK and an internship on how neutrophils promote breast cancer dissemination at the Netherlands Cancer Institute in Amsterdam. She joined the department of Tumor immunology for an internship on immunosuppressive pathways in dendritic cell subsets, after which she started her PhD research with Prof. Carl Figdor in 2014 working in the interdisciplinary fields of chemical immunology and immunoengineering. Jorieke is interested in exploiting biomaterial-based scaffolds as tools to locally boost the anti-cancer immune response, specifically dendritic cells and tumor-specific T cells. Jorieke's primary advisor is Prof. Carl Figdor..

Anouk Becker, MSc Researcher ID: S-5539-2018

Anouk.Becker@radboudumc.nl

Anouk obtained her Master’s degree in Molecular Mechanisms of Disease from the Radboud University Nijmegen in 2018. Her passion for immunology became apparent during her Bachelor internships in Brisbane and Nijmegen, in which she worked on dendritic cell subsets. For her first master internship she joined the Verdoes Lab and discovered the exciting interdisciplinary field of chemical immunology. She wrote her master thesis at Harvard Medical School in Boston, focusing on the role of an AMPylase in antibody folding and secretion. For her PhD, she wrote a project together with Dr. Verdoes and Prof. de Vries that combines her interest for dendritic cells with chemical immunology. She aims to develop chemistry-based delivery systems to modulate immunosuppressive cells in the tumor microenvironment. Anouk is co-supervised by Prof. Jolanda de Vries.

Technicians

Duco van Dalen, BSc

Duco.vanDalen@radboudumc.nl

After an internship in the group of Huib Ovaa, department of Chemical Biology at the Netherlands Cancer Institute (NKI), Duco van Dalen obtained his BsC in organic chemistry at the University of Applied Sciences in Leiden in August 2012.

His life took another direction; he raised the charity ‘Longest Breath’, to create awareness about the dangers and effects of the misuse of asbestos. On March 31st 2013 he began a cycling journey of nine thousand kilometre, from China back to the Netherlands. This all in memory of his father, who died in 2011 as a result of mesothelioma caused by exposure to asbestos (for more information please visit: www.LongestBreath.com).

After two and a half years voluntary work for the charity, he picked up his chemistry career and started working in an analytical lab. But the Biochemistry side kept his interest and he rejoined in 2015 the research group of Huib Ovaa.

End 2016 Martijn Verdoes gave him the opportunity to work for him as technician in his research group. “This opportunity fitted exactly in my dream to live and work in a less busy and more greener environment. To be part of the newly formed research group lead by Martijn Verdoes and work together right at the frontline of the cancer research is highly motivating.” as quoted by Duco.

 

BSc / MSc students

Liyan Smeding, BSc

Liyan.Smeding@radboudumc.nl

Liyan obtained her Bachelor’s in Biomedical Sciences at the Radboud University Nijmegen in 2017. During the Bachelor Honours Programme Medical Sciences she developed her interested in biomedical research. In the fall of 2017 she started the research master, Molecular Mechanisms of Disease from the Radboud Institute for Molecular Life Sciences (RIMLS). With a biomedical background, the courses on immunology and genetics sparked her interest in immunotherapy. During her internship she is working with Felix Fenneman on producing anti-cancer vaccines.

 

Former lab members

Liping Qiu, PhD

qiuliping@hnu.edu.cn

Postdoc

Current position:

Assistant Professor

Hunan University · College of Chemistry and Chemical Engineering

Anouk Becker, BSc

Anna.Becker[at]radboudumc.nl

MMD master student

Valerie Betting, BSc

valerie.betting[at]student.ru.nl

MMD master student